Chronic Hepatitis B
Conditions
Brief summary
The aim of our study is to evaluate liver fibrosis using biochemical markers, FibroScan, and radiology methods in patients with chronic hepatitis B in mainland China.
Detailed description
Up to Nov, 2015, total of 818 patients with chronic HBV infection had been enrolled in the study. Paired blood and liver biopsy specimen had been collected. The serum samples stored at -80 degree Celsius. All the liver biopsy samples were judged by three pathology experts, according to Ishak standard.
Interventions
None listed
Sponsors
Beijing Municipal Science & Technology Commission
Peking University First Hospital
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of chronic hepatitis B or compensated cirrhosis due to chronic hepatitis B virus infection * agree to have liver biopsy
Exclusion criteria
* clinical diagnosis of decompensated cirrhosis due to hepatitis B virus or inactive carrier * liver diseases due to other origin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of staging fibrosis with a combination of non-invasive parameters compared to liver biopsy | within two weeks after liver biopsy |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of staging inflammation with a combination of non-invasive parameters compared to liver biopsy | within two weeks after liver biopsy |
Countries
China
Outcome results
None listed