Dietary Prevention
Conditions
Keywords
LDL-cholesterol
Brief summary
The purpose of this study is to investigate blood LDL-cholesterol and level of inflammatory markers after intake of food items with different fatty acid composition.
Interventions
OTHERFood items
Food items with different fatty acid composition
Sponsors
Oslo Metropolitan University
Mills DA
University of Oslo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* hsCRP \< 10 mg/L * total cholesterol 5-7.8 mmol/l(50-70 y) * total cholesterol 5.0-6.9 mmol/l (30-49 y) * total cholesterol 5.0-6.1 mmol/l (25-29 y) * LDL-cholesterol at or above 3.5 mmol/l * triglycerides at or lower 2.6 mmol/l * BMI 20-35 * Stable bodyweight last 3 months.
Exclusion criteria
* Chronic diseases * fasting glucose \> 6.0 mmol/l * increased ASAT and ALAT * medications affecting lipidmetabolism and inflammation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in LDL-cholesterol | Change from baseline after 8 weeks | Change in LDL-cholesterol when compared to control diet |
| Change in total cholesterol | Change from baseline after 8 weeks | Change in total cholesterol when compared to control diet |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite hormones | Appetite hormones is measured at baseline and after 8 weeks of intervention | — |
| Gut peptides | Gut peptides are measured at baseline and after 8 weeks of intervention | — |
| Inflammatory markers in circulation and at gene expression level in PBMC | Inflammatory markers are measured at baseline and after 8 weeks intervention in circulation and at gene expression level in PBMC | — |
| Whole genome gene expression | whole genome gene expression profiles are measured at baseline and after 8 weeks of intervention | Microarray |
| Metabolites | Metabolites are measured at baseline and after 8 weeks of intervention | Targeted and untargeted metabolomics will be measured |
| Markers of lipid metabolism at gene expression level in PBMC | Markers of lipid metabolism at gene expression level in PBMC is measured at baseline and after 8 weeks of intervention | — |
Countries
Norway
Outcome results
None listed