Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers

Double Blind, Randomized, Placebo-controlled Clinical Trial of the Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Current Heavy Smokers

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01677169

Enrollment

317

Registered

2012-08-31

Start date

2000-09-30

Completion date

2006-08-31

Last updated

2019-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DNA Damage

Brief summary

The purpose of this study was to determine if noni juice reduces lipid hydroperoxide (LOOH) and malondialdehyde (MDA) derived-DNA adducts, markers of oxidative DNA damage, in peripheral blood lymphocytes of cigarette smokers.

Interventions

DIETARY_SUPPLEMENTNoni juice

Ingestion of noni juice, a source of iridoids, daily for 30 days.

DIETARY_SUPPLEMENTPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 to 65 years in age, smoker of more than 20 cigarettes per day, a smoking history exceeding one year, and willing to complete a one month trial.

Exclusion criteria

* concurrent use, or use in the previous three months, of prescription medication or antioxidant vitamins

Design outcomes

Primary

Measure	Time frame	Description
LOOH and MDA-DNA adducts	1 month	LOOH and MDA-DNA adducts in lymphocytes immediately prior to intervention and at completion of intervention.

Secondary

Measure	Time frame	Description
adverse events	1 month	Adverse health events

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026