Benign Prostate Hyperplasia
Conditions
Keywords
Hyperbaric Levobupivacaine, İntrathecal, Lidocaine, TUR-P
Brief summary
The main objective was to test the hypothesis that adding lidocaine to hyperbaric levobupivacaine could change the duration of levobupivacaine spinal block.
Detailed description
A satisfactory spinal anaesthesia requires both a fast onset and proper duration at the same time. Transurethral resection of the prostate (TUR-P) is a surgery of medium duration. The addition of lidocaine to hyperbaric bupivacaine shortens the duration of bupivacaine spinal block and therefore provides more rapid recovery. This property of lidocaine is not verified with other local anesthetics. Levobupivacaine is a S-enantiomer of racemic bupivacaine and is a long acting local anesthetic.The aim of this prospective randomized controlled study was to investigate this effect of lidocaine, with a local anesthetic other than bupivacaine. It was hypothesized that the duration of the intrathecal block could change when performed with hyperbaric levobupivacaine mixed with low dose lidocaine and this technique could be consistent for the duration of TUR-P surgery. Participants will be followed on the day of surgery for primary and secondary outcome measures and 3 days postoperatively for complications (TNS).
Interventions
DRUGLevobupivacaine lidocaine spinal anesthesia
Spinal anesthesia
DRUGlevobupivacaine Spinal anesthesia
spinal anesthesia
Sponsors
Diskapi Teaching and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* elective transurethral resection of the prostate (TUR-P)
Exclusion criteria
* patients with contraindications for spinal anesthesia, * known sensitivity to the study drugs, * emergency cases, and * patients who refused spinal anaesthesia were excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The duration of the spinal block (S1 regression of the block) | participanta will be followed on the operation day | the time between the intrathecal injection and sensorial block regression to S1 dermatome, measured in minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative care unit stay | participants will be followed on the operation day | the time between the patient entered the PACU and left the PACU (when the sensorial block was regressed to S1 dermatome and the patient fulfilled an Aldrete score higher or equal to 9), measured in minutes |
Other
| Measure | Time frame | Description |
|---|---|---|
| maximum block level | participants will be followed on the operation day | the dermatomal level that the sensorial block reached, determined with the pin prick test, expressed with dermatomes |
Countries
Turkey (Türkiye)
Outcome results
None listed