Computer-assisted Cognitive Rehabilitation (CACR), Placebo CACR and Psycho-stimulants in the Treatment of ADHD

A Randomized Clinical Trial Comparing Computer-assisted Cognitive Rehabilitation (CACR), Psycho-stimulants, and Placebo CACR in the Treatment of Attention Deficit/ Hyperactivity Disorder

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01675804

Enrollment

Registered

2012-08-30

Start date

2011-11-30

Completion date

2012-05-31

Last updated

2015-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention Deficit Disorder With Hyperactivity

Keywords

ADHD

Brief summary

Current research aimed to compare the efficacy of computer-assisted cognitive rehabilitation (CACR), stimulant drugs and Placebo CACR on executive functions and clinical symptoms of children with attention deficit/hyperactivity disorder (ADHD).

Detailed description

The investigators administered a randomized controlled trial (RCT) through random assignment of ADHD subjects in to three different groups to compare the effects of CACR, immediate-release methylphenidate, and a Placebo CACR (i.e. some computerized tasks assumed not having any therapeutic effects) on the functioning of children with ADHD.

Interventions

OTHERComputerized cognitive rehabilitation

\- Computerized cognitive rehabilitation: 20 ninety-minute sessions of computerized cognitive rehabilitation.

DRUGRitalin

-drug therapy: 2 or 3 doses of 10 mg tablets of Immediate-release Methylphenidate (Ritalin) per day for 2 months.

OTHERPlacebo CACR [PCACR]

PCACR: 20 ninety-minute sessions of Placebo computerized cognitive training.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

7 Years to 12 Years

Healthy volunteers

Inclusion criteria

* ADHD diagnosis * age between 7 and 12 * IQ \> 85

Exclusion criteria

* sever co-morbid disorder * seizure * IQ \< 85 * disability * sever medical condition

Design outcomes

Primary

Measure	Time frame	Description
Persian software for the continuous performance test [CPT]	5 months	The Persian software of CPT is a visual CPT test.
Persian software for the Tower of London Test [TOL]	5 months	Persian TOL is a software version of tower of London test (TOL) which was developed in Iran.
Forward/Reversed digit span tasks from the WISC-R testing battery.	5 months	Reversed digit span from the WISC-R (Wechsler, 1974) was used to measure executive verbal WM and the forward digit span was used to measure short-term memory.
Raven's colored progressive matrices.	5 months	Raven's colored progressive matrices (Raven, 1995) was used to measure complex non-verbal reasoning.
Span board task from the Lumosity.com online software (Lumosity.com, 2012)	5 months	—
SNAP-IV scales	5 months	—

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026