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Topical Nitrates for Myofascial Trigger Points

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01675700
Enrollment
10
Registered
2012-08-30
Start date
2009-01-31
Completion date
2009-12-31
Last updated
2012-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myofascial Trigger Points

Keywords

Myofascial pain, Trigger point, Nitroglycerin

Brief summary

The purpose of this study is to determine whether a topical nitroglycerine patch applied daily over a trapezius trigger point can improve patients' symptoms. If there is improvement, this open label study will help determine the degree of improvement and contribute to the design of a larger double blind placebo controlled trial. We would consider moving forward to a large randomized trial if: * The intervention is acceptable to patients (\>= 70%) and * Compliance is satisfactory (\>=80%) and * We find preliminary evidence of efficacy, i.e. average reduction in pain of 20mm on the VAS.

Interventions

Nitroglycerin 0.1 mg/hr patch

Sponsors

GF Strong Rehabilitation Centre
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Inclusion criteria include age between 19 and 65 years old, myofascial pain lasting at least 6 months, and a myofascial trigger point point in the trapezius muscle.

Exclusion criteria

* Our

Design outcomes

Primary

MeasureTime frame
Pain at the time of clinic visit and over the previous week as measured by a Visual Analog Scale, VAS, for pain and a pressure algometer measurement to obtain pressure pain thresholds over the patients trigger point.1 month

Secondary

MeasureTime frame
As another secondary outcome we will ask the participants whether the benefits of the treatment are good enough that they would continue using the nitroglycerin patch. This will be a yes or no response.1 month

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026