Kidney Failure, Chronic
Conditions
Keywords
hemodialysis, blood pressure variability, volume status
Brief summary
The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.
Detailed description
Hemodialysis patients experience higher rates of cardiovascular morbidity and mortality than the general population and many populations with other chronic diseases. This exceptional risk is explained in part by known risk factors such as diabetes, hypertension, and other uremia-related factors, including vascular calcification and stiffness, autonomic dysfunction, and a high burden of circulating inflammatory mediators. However, additional unidentified risk factors also likely contribute to the disproportionately high prevalence of cardiovascular morbidity in hemodialysis patients. Blood pressure variability may represent one plausible cardiovascular risk factor. Data from nonuremic human populations show an association between greater blood pressure variability and cardiovascular events,nonfatal cardiovascular events,stroke,and increased left ventricular mass. There has been comparatively little work examining the causes and effects of blood pressure variability in hemodialysis populations. So the purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.
Interventions
None listed
Sponsors
Beijing Chao Yang Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
24 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age 18 years or older * receipt of thrice-weekly in-center hemodialysis * no anticipation of imminent(\<6 months)living related kidney transplant * not transfer of care to a nonparticipating facility * no dialytic modality change * free of vascular, infectious, or bleeding complication within 1 month
Exclusion criteria
* who missed \>2 hemodialysis treatments over 1 month * abused drugs * severe anemia，malnutrition，chronic atrial fibrillation * body mass index of 40 \>kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| interdialytic blood pressure | 44 hours | Ambulatory BP monitoring was performed after the midweek hemodialysis session for 44 hours. Ambulatory BPs were recorded every 20 minutes during the day (6 AM to 10 PM) and every 30 minutes during the night (10 PM to 6 AM) in the nonaccess arm, We use the coefficient of variation or standard deviation in interdialytic blood pressure as a indicator of systolic blood pressure variability. |
Countries
China
Contacts
Primary ContactCui TG Taigen, Dr.
Backup ContactMa WH Weihua, Master
Outcome results
None listed