Aging, Heart Failure, Sarcopenia
Conditions
Keywords
Eccentric exercise, Aging, Heart failure, Muscle strength loss, Sarcopenia
Brief summary
The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.
Detailed description
Study design: Twelve elderly males with chronic heart failure, New York Heart Association class I-II, will participate in this study. Participants will be allocated into two equally-sized groups: a stair descending group (n = 6) and a stair ascending group (n = 6). At the beginning of the study, the volunteers will perform an acute bout of stair descending or stair ascending exercise on an automatic escalator (4 sets of 3 min each, speed will be set at 45 steps∙min-1). Step height will be 20.5 mm. Before and at day 2 post exercise, physiologic measurements will be performed and blood samples will be collected. Then, participants will carry out six weeks of stair descending or ascending training consisting of three exercise sessions per week (the first two weeks the speed will be set at 45 steps∙min-1, the next two weeks at 50 steps∙min-1 and the last two weeks at 55 steps∙min-1 for both groups). Afterward, they will repeat the acute stair descending or ascending protocol, as carried out at the beginning of the study, and the same physiologic measurements will be performed and blood samples will be collected. Measurements: Isometric (at 90 knee flexion), concentric and eccentric peak torque at 60o∙s-1of quadriceps femoris, pain-free range of motion, delayed onset muscle soreness and creatine kinase will be measured.
Interventions
OTHERExercise
Comparison between stair descending and stair ascending training
Sponsors
University of Thessaly
Aristotle University Of Thessaloniki
European University Cyprus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
60 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* chronic heart failure (New York Heart Association class I-II) * subject provides written informed consent * personal physician of the participants provides written informed consent
Exclusion criteria
* smoker * consumed any nutritional supplement the last 3 months * performed intense eccentric exercise the last 6 months * non Caucasian
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength (torque) | Change from baseline in muscle strength at day 2 post exercise at the first and sixth week of training | An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain free range of motion (degrees) | Before and at day 2 post exercise at the first and sixth week of training | The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort. |
| Creatine kinase, CK (activity IU) | Before and at day 2 post exercise at the first and sixth week of training | CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer. |
| Delayed onset muscle soreness, DOMS (scale 1-10) | Before and at day 2 post exercise at the first and sixth week of training | Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore). |
Countries
Cyprus
Outcome results
None listed