Atrial Fibrillation
Conditions
Keywords
Atrial fibrillation, Exercise
Brief summary
This is a substudy of Generation 100. The investigators will follow the persons with atrial fibrillation to see if 3 years of interval or moderate exercise affects the burden of atrial fibrillation, symptoms, use of health services or echocardiographic findings.
Interventions
BEHAVIORALInterval exercise
4 times of 4 minutes intervals at an intensity of 90-95% of maximum heart rate and active pauses of 3 minutes between intervals. 3 times a week for 3 years.
BEHAVIORALModerate exercise
Moderate exercise with pulse about 70% of max pulse; 3 times a week for 3 years.
BEHAVIORALControl
Given information on recommendations for physical activity.
Sponsors
St. Olavs Hospital
SINTEF Health Research
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
70 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Included in the Generation 100 study * Atrial fibrillation diagnosis verified by ECG
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in burden of atrial fibrillation | At baseline and 3 years | Burden of atrial fibrillation; measured by Holter monitor and the patient. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life | At baseline and 3 years | Measured with SF-36 |
| Endothelial function | At baseline and 3 years | Diameter of brachial artery measured by ultrasound. |
| Maximal oxygen uptake | At baseline and 3 years | — |
| Atrial extrasystoles | At baseline and 3 years | Measured with Holter monitor |
| Number of hospitalisations with atrial fibrillation as main diagnosis | Total number during the 3 year intervention period | — |
| Size of left ventricle | At baseline and 3 years | Echocardiographic measures |
| Change in burden of atrial fibrillation | Baseline and 1 year | Measured by Holter and the patient. |
| Size of left atrium | Baseline and 1 year | Echocardiography |
| Function of left atrium | At baseline and 3 years | Echocardiographic measures |
| Function of left ventricle | At baseline and 3 years | Echocardiographic measures |
| Symptom burden | At baseline and 3 years | Measured with Symptom and Severity Checklist. |
| Total number of electrical cardioversions | During the 3 years of intervention | Number of electrical cardioversions because og atrial fibrillation |
Countries
Norway
Outcome results
None listed