CPAP, Hypoxic Ventilatory Response, Neuromuscular Blockade, OSA, Rocuronium
Conditions
Brief summary
This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.
Interventions
DRUGRocuronium
Partial neuromuscular blockade with rocuronium with a TOF 0.70
Sponsors
Malin Jonsson Fagerlund
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI \<35.
Exclusion criteria
* If they don´t fit the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxic ventilatory response | At baseline, with CPAP, at TOF 0.70 and at TOF >0.90. At diagnosis and after 3 month of CPAP treatment at home |
Secondary
| Measure | Time frame |
|---|---|
| Hypercarbic ventilatory response | At baseline, with CPAP, at TOF 0.70 and at TOF >0.90. At diagnosis and after 3 month of CPAP treatment at home |
| Hypoxic ventilatory response | At diagnosis and after 3 month of CPAP treatment at home |
| Hypoxic ventilatory response during acute CPAP treatment | At diagnosis and after 3 month of CPAP treatment |
| Hypercarbic ventilatory response during acute CPAP treatment | At diagnosis and after 3 month CPAP treatment at home |
| Upper airway obstruction | At TOF 0.70 and TOF >0.90. At diagnosis and after 3 month CPAP treatment. |
Countries
Sweden
Outcome results
None listed