Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism

Incidence of CTEPH in Dependence of Thrombus Location in Patients With Acute Pulmonary Embolism and Index Fibrinolysis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01672203

Enrollment

500

Registered

2012-08-24

Start date

2009-01-31

Completion date

2012-11-30

Last updated

2012-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CTEPH

Brief summary

Chronic thromboembolic pulmonary hypertension (CTEPH) has been associated with increased morbidity and mortality. Patients with pulmonary embolism (PE) have elevated risk for development of CTEPH. It is not known, whether the location of pulmonary embolism (central vs. peripheral) nor fibrinolysis have an impact of CTEPH incidence. This study has been performed to assess the CTEPH incidence in different populations: in patients with central vs. peripheral PE and in patients with or without fibrinolysis therapy for PE.

Detailed description

The embolus localization during index pulmonary embolism might be of potential relevance for CTEPH development. In the present study patients with confirmed pulmonary embolism for at least 12 months will be screened for CTEPH. The incidence of CTEPH will be correlated to thrombus location (central vs. peripheral) and the index use of fibrinolysis.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* acute pulmonary embolism for at least 12 months

Exclusion criteria

* known pulmonary hypertension other than CTEPH

Design outcomes

Primary

Measure	Time frame	Description
CTEPH	participants will be followed at least one year after acute pulmonary embolism, an expected average of 5 years follow-up is estimated	Incidence of CTEPH

Countries

Germany

Contacts

Primary ContactFikret Er, MD

fikret.er@uk-koeln.de+49-221-478-32396

Backup ContactNatig Gassanov, MD

natig.gassanov@uk-koeln.de+49-221-478-32354

Outcome results