The Association Between Monocyte Subsets and Coronary Collateral Development in Diabetes Mellitus

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01671306

Enrollment

Registered

2012-08-23

Start date

2011-01-31

Completion date

2011-10-31

Last updated

2012-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary collaterals, diabetes mellitus, monocyte subsets

Brief summary

Monocyte heterogeneity in peripheral blood seems to be important in coronary collateral development in non-diabetic patients with stable coronary artery disease. Our aim in this study is to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development in type 2 diabetic patients.

Detailed description

83 diabetic patients with severe coronary artery disease were enrolled in the study. These patients were investigated according to their collateral development. Monocytes and their subtypes, namely CD14++CD16- and CD14+CD16+ cells were compared in 2 groups

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Inclusion criteria

* presence of \> 95% stenosis of at least one major coronary artery in their first coronary angiogram.

Exclusion criteria

* Patients experiencing acute coronary syndrome either with or without ST elevation in the last one month * Evidence of ongoing infection and inflammation, known malignancy and chronic kidney disease

Outcome results