Genetics Study of In-stent Restenosis

G Protein β3 Subunit (GNB3) Polymorphism and Restenosis of Coronary Drug-eluting Stents

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01670396

Acronym

ISR

Enrollment

300

Registered

2012-08-22

Start date

2012-03-31

Completion date

2012-09-30

Last updated

2012-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

coronary stent implant, polymorphism, G protein, drug-eluting stent, restenosis

Brief summary

The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).

Detailed description

Although drug-eluting stents (DES) have reduced restenosis rates compared with bare-metal stents, the restenosis rate is still high in the high-risk group. G protein plays important roles in the signal transduction leading to vascular smooth muscle proliferation. The initial and subsequent studies suggest that the T allele of C825T polymorphism is associated with enhanced transmembrane signaling via Gi proteins.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who underwent follow-up angiography. All the patients must had been implanted with DES during the last two years.

Exclusion criteria

* For the non-ISR group, the patients underwent follow-up angiography less than 6 months away from stent implanting.

Design outcomes

Primary

Measure	Time frame
In-stent restenosis	6-24months after stent implanting

Secondary

Measure	Time frame
target lesion revascularization (TLR)	6-24months after stent implanting
re-myocardial infarction	6-24months after stent implating

Countries

China

Contacts

Primary ContactYamei Xu

xu.yamei@zs-hospital.sh.cn8613917133371

Outcome results