Fractures, HIV Infection, Osteoporosis
Conditions
Keywords
HIV, Bone mineral density, Osteoporosis, Vitamin D, Fractures
Brief summary
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups. This will enable a practical approach to screening for osteoporosis and the management and prevention of fragility fractures in people with HIV. In addition, all risk factors commonly associated with fragility fractures and osteoporosis are collected, as is HIV drug history. Hence, as secondary outcomes, the associations with reduced bone mineral density can be ascertained.
Interventions
None listed
Sponsors
St Thomas' Hospital, London
King's College London
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years or above Not pregnant Able to comply with study observations and procedures Able to give fully informed consent
Exclusion criteria
* Pregnant Less than 18 years of age Unable to comply with study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone mineral density at Hip | The outcome is measured within 6 months (0-6 months) after entry to the study. | Bone mineral density as determined by DXA scanning |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bone mineral density at spine (L4) | The outcome is measured within 6 months (0-6 months) after entry to the study. | As determined by DXA scan |
| Any lifetime fractures reported by subjects | At any stage during persons life up to and including the last visit for the volunteer to the study. | Self-reported fractures of any type |
| Vitamin D levels | The outcome is measured within 6 months (0-6 months) after entry to the study. | Plasma vitamin D |
Countries
United Kingdom
Outcome results
None listed