The Effect of Parenteral Nutrition Supplement on Esophagectomy Patients

The Effect of Parenteral Nutrition Supplement Versus Enteral Nutrition Alone on Nutrition Status After Esophagectomy: A Prospective Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01669356

Enrollment

Registered

2012-08-21

Start date

2012-07-31

Completion date

2014-03-31

Last updated

2014-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophagus Cancer

Keywords

malnutrition, parenteral supplement, rest metabolic rate, postoperative complications

Brief summary

Malnutrition is common in esophagus cancer patients, especially after surgery therapy. Whether parenteral supplement with enteral nutrtion is benificial for patients after esophagectomy is controversial, when compared with enteral nutrition alone. In this study, the investigators are to examine the effect of enteral nutrition supplemented with parenteral nutrtion on nutrition status after esophagectomy.

Interventions

OTHERParenteral supplement with enteral nutrition for patients after esophagectomy

OTHEREnteral Nutrition alone for patients after esophagectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of esophagus cancer * Undergo esophagectomy * Nasoenteral tube is placed or surgical jejunostomy is performed

Exclusion criteria

* Contraindication for enteral nutrition or parenteral nutrition * Malnutrition before surgery ( BMI \> 30 or \< 18.5) * Hepatic dysfunction preoperatively * Renal dysfunction preoperatively * Infection before surgery * Usage of corticosteroid before surgery

Design outcomes

Primary

Measure	Time frame	Description
postoperative laboratory parameters changes for nutrition assessment compared to preoperation	from one day before surgery to the 7th postoperative day	plasma albumin, prealbumin, transferrin, retinaldehyde-binding protein, total lymphocytes counts
postoperative body composition change compared to preoperation measurement	from one day before surgery to the 7th postoperative day	postoperative body composition is compared to preoperation, bioelectrical impedance spectroscopy is used for measurement of body composition

Other

Measure	Time frame	Description
complicatons incidence after surgery	28 days after surgery	complications involve anastomotic leakage, incision infection, pneumonia, catherter-related blood stream infection, respiratory failure

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026