Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01668446

Acronym

sildenafil

Enrollment

Registered

2012-08-20

Start date

2009-09-30

Completion date

2011-02-28

Last updated

2012-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Preparation, Frozen Embryo Transfer

Keywords

Sildenafil, Endometrial thickness, Frozen embryo transfer, ultrasonographic endometrial thickness, endometrial pattern, Implantation rate, chemical pregnancy rate

Brief summary

The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

Interventions

DRUGSildenafil

sildenafil tablets(50 mg) daily

DRUGestradiol valerat

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 39 Years

Healthy volunteers

Yes

Inclusion criteria

* women \> 40 years old, * history of endocrine disease * Hysteroscopic surgery * cardiovascular, renal and liver disease * hypotension( blood pressure \< 90/50) * history of stroke or myocardial infarction * use of alcohol or substance

Exclusion criteria

A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be \< 40 years old, * no history of endocrine disease, * no Hysteroscopic surgery, had a high quality embryos no cardiovascular, * renal and liver disease and * no hypotension (blood pressure \< 90/50) or * history of stroke or myocardial infarction and * don't use of alcohol or substance Patients with these conditions enter this study and based on randomized tables are divided in two groups.

Design outcomes

Primary

Measure	Time frame	Description
estimate the result of sildenafil on ultrasonographic endometrial thickness	between 2009-2011 (up to 2 years)	Assays: Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred.

Secondary

Measure	Time frame	Description
estimate the result of sildenafil on Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .	between 2009-2011 (up to 2 years)	Implantation rate was higher in sildenafil Group but not significant chemical pregnancy rates were higher in sildenafil Group but not significant.

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026