Immunocompetent Patient on Septic Shock
Conditions
Keywords
Septic shock, Inflammatory process, Cytokines, Hormonal response, Oxydative stress
Brief summary
Septic shock is a frequent pathology responsible for over 30000 deaths/year in France. Its outcome has not been improved despite the knowledge on inflammatory processes; a reason for these lack of results may lay on the lack of data on the precise dynamics of inflammatory and anti-inflammatory cascades and their consequences. We intend to achieve accurate monitoring of the inflammatory process on a small group of non-immunocompromised patients. Our goal is to obtain quality data, repeated over time, by limiting the technical variability.
Detailed description
The aim is to obtain precise data on the dynamics of cytokines, oxydative stress and hormonal response on immunocompetent adults during septic shock.
Interventions
None listed
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient over 18 years admitted in ICU. * Clinical evidence of infection, suspected or proved, during the 48hrs following the hospital entry. * Systemic inflammatory response syndrome. * Shock defined as arterial hypotension (\<90mmHg)not responding to adequated filling.
Exclusion criteria
* Minors * Patient under guardianship or trusteeship * Pregnant or lactating women * Not affiliated to the social security * Deprived of liberty by court decision * Patients hospitalised without their approval * Shock related to another cause than infection * Long term corticothérapy * On-going chemiothérapy, AIDS * Bedridden patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evolutive profile of the inflammatory response during septic shock | Hospitalisation in ICU |
Secondary
| Measure | Time frame |
|---|---|
| Research for early prognosis factors | Hospitalisation in ICU |
Countries
France
Outcome results
None listed