Dyspepsia, H-pylori, Peptic Ulcer
Conditions
Keywords
H-pylori, eradication, azithromycin, clarithromycin
Brief summary
The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.
Detailed description
Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries. There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.
Interventions
DRUGazithromycin
Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.\[1\] It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.
DRUGclarithmycin
Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.
Sponsors
Shahid Sadoughi University of Medical Sciences and Health Services
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy
Exclusion criteria
* patients who got H-pylori eradication treatment previously * patients who used study drugs during 3months before study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| H-pylori cinfirmation | 1-3 months before study | confirmation is by endoscopy and biopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| h-pylori eradication confirmation | two months after completion of 14 days standard treatment | confirmation of eradication was by endoscopy and biopsy |
| side effect of study srugs | during 14 days standard treatment | it was assessed by researcher and self report of patients. variables like nausea, vomiting and diarrhea. the prevalence of each treatment related complain was registered by taking history from patients. |
Countries
Iran
Outcome results
None listed