Ischemic Reperfusion Injury
Conditions
Brief summary
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
Interventions
DIETARY_SUPPLEMENTAntioxidant
DRUGProstaglandin inhibitor (Ibuprophen)
Sponsors
University of Essex
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy males * Healthy females
Exclusion criteria
* Smokers * Cardiovascular disease * Peripheral vascular disease * Neurological deficits * Diabetes Type I or II * Pregnant women * Adverse reactions to Ibuprofen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in flow mediated dilation | Change from baseline at 15 minutes after ischemia-reperfusion injury | Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in low flow mediated constriction | Change from baseline at 15 minutes after ischemia-reperfusion injury | low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury |
Countries
United Kingdom
Outcome results
None listed