Omega-3 Fatty Acid Supplementation in Older Adults

The Impact of Omega-3 Fatty Acid Supplementation on Markers of Inflammation and Lean Body Mass in Older Adults

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01666392

Enrollment

Registered

2012-08-16

Start date

2012-08-31

Completion date

2013-04-30

Last updated

2012-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Keywords

Omega-3 fatty acid, Fish oil, Muscle mass, Muscle strength, Older adults, Circulating inflammatory cytokines, Skeletal muscle mass, Upper body strength, Lower body strength

Brief summary

The purpose of this study to determine whether Fish oil (Omega-3 Fatty Acid) supplementation has an impact on inflammation and lean body mass in older adults. The investigators expect that Fish oil supplementation will reduce inflammation and prevent the loss of lean mass compared to placebo.

Interventions

DIETARY_SUPPLEMENTOmega-3 fatty acid

Omega-3 fatty acid, Eicosapentaenoic acid+docosahexaenoic acid in capsule form

DIETARY_SUPPLEMENTPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 60 years of age or over

Exclusion criteria

* Fish, seafood allergies, nut allergies, soy allergies * Habitual (\>1/week) fish or seafood consumption * Current Omega-3 supplement use * Gastrointestinal problems * Current anti-inflammatory medication use * Current anticoagulant medication use

Design outcomes

Primary

Measure	Time frame	Description
TNFα	At baseline and at 3 month endpoint	Inflammatory cytokine
C-Reactive protein	At baseline testing and at 3 month endpoint	Inflammatory marker
IL6	At baseline and at 3 month endpoint	Inflammatory cytokine

Secondary

Measure	Time frame	Description
Upper body muscular strength	At baseline and at 3 month endpoint	Measurement of maximum strength in the chest press exercise
Skeletal muscle mass/body composition	At baseline testing and at 3 month endpoint	The amount of skeletal muscle mass and fat mass and their ration will be determined.
Lower body muscular strength	At baseline and at 3 month endpoint	Measurement of maximum strength in the leg press exercise

Other

Measure	Time frame	Description
EPA and DHA	At baseline and at 3 month endpoint	To determine the effectiveness of fish oil supplementation, we measure EPA and DHA Omega-3 fatty acid levels

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026