Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome

Adding L-carnitine in Clomiphene Resistant Pco Improves the Quality of Ovulation and the Pregnancy Outcome,a Randomized Clinical Trial

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01665547

Enrollment

157

Registered

2012-08-15

Start date

2012-07-31

Completion date

2013-09-30

Last updated

2013-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment Resistant Disorders

Keywords

clomiphene resistant, pcos, induction of ovulation, l-carnitine

Brief summary

Adding L-carnitine is more successful than clomiphene as a first line therapy for ovulation induction in women with clomiphene resistant PCOS

Detailed description

Patients younger than 35 years, presenting with primary or secondary infertility following regular intercourse for at least 1 year and diagnosed with PCO according to Rotterdam's criteria who had received five unsuccessful clomiphene citrate-timed intercourse stimulation cycles were included.

Interventions

DRUGl-carnitine

3gm l-carnitine from day 1 to day 12 of the menstrual cycle

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients younger than 35 years, presenting with primary or secondary infertility following regular intercourse for at least 1 year and diagnosed with PCO according to Rotterdam's criteria who had received five unsuccessful clomiphene citrate-timed intercourse stimulation cycles were included. The diagnosis was based on a complete history taking, physical examination and a paper documented complete infertility work-up within the previous 6 months, either conducted within the setting of the hospital or at a licensed infertility management clinic.

Exclusion criteria

* age more than 40 years, * tubal,uterine or male factor infertility

Design outcomes

Primary

Measure	Time frame	Description
ovulation induction	0ne year	is to study the efficacy of l-carnitine in inducing ovulation in clomiphene resistant pco

Secondary

Measure	Time frame	Description
pregnancy	0ne year	the occurrence of pregnancy and the rate of continuation of pregnancy till end of the first trimester

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026