Coronary Artery Diseases
Conditions
Keywords
18-F Sodium Fluoride, Acute coronary syndrome, Stable Angina
Brief summary
The purpose of this study is to evaluate the correlations between active calcification and vulnerable plaque.
Interventions
OTHER18-F Sodium Fluoride Uptake in Positron emission tomography
Sponsors
CHEOL WHAN LEE, MD, PhD.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age more than 20 * Acute coronary syndrome or stable angina
Exclusion criteria
* Contraindications to the use of heparin, aspirin, clopidogrel, stainless metal, contrast media * Acute ST segment elevation myocardial infarction within 12hours, heart failure, cardiac shock * Any serious medical comorbidity such that the subject's life expectancy is less than 24 months * Ejection fraction less than 30 * Serum creatinine level of 1.5mg/dl and over * Vasculitis * Unwillingness or inability to cooperate or to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized 18F-NaF uptake value within the culprit plaque | At the time of diagnosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The relationship between 18F-NaF uptake value and calcium scores by Multidetector Computed Tomography | at the time of diagnosis | — |
| The relationship between 18F-NaF uptake value and plaque types by Multidetector Computed Tomography | at the time of diagnosis | — |
| The relationship between 18F-NaF uptake value and biomarkers | at the time of diagnosis | hs-CRP, Troponin-I |
| The relationship between 18F-NaF uptake value and invasive imagings | at the time of diagnosis | Intravascular ultrasound, Optical coherence tomography |
Countries
South Korea
Outcome results
None listed