Pregnancy, Ectopic
Conditions
Brief summary
The aim of this study was to compare single dose Methotrexate (MTX) to multiple dose MTX.
Interventions
DRUGSingle
In the single dose regimen, 50 mg/m2 intramuscular methotrexate was given on day one and hCG level was measured on days four and seven. If the hCG level did not decrease by 15% between day four and seven, a second dose of methotrexate was injected on day seven, hCG level was measured weekly until a level of 15 mlU/ml or less was achieved
DRUGMultipe
In the multiple dose regimen, 1 mg/kg/day intramuscular methotrexate was given on days one, three, five and seven and 0.1 mg/kg/day intramuscular Citrovoram factor was administered on days two, four, six and eight until serum hCG level decreased 15% in 48 hours or four doses of methotrexate was given weekly until serum hCG level of 15 mlU/ml or less was obtained
Sponsors
Hormozgan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* unruptured tubal EP * gestational mass of less than or equal to 3.5 cm in ultrasonography report
Exclusion criteria
* hemodynamic instability * contraindications related to the use of MTX * hepatic * renal and active pulmonary diseases * peptic ulcer * immune deficiency status * alcohol abuse * blood dyscreasia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hCG level decrease | 4 days after administration |
Countries
Iran
Outcome results
None listed