The Effect of Humidification on Mucus Rheology

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01661374

Enrollment

Registered

2012-08-09

Start date

2012-07-31

Completion date

2014-04-30

Last updated

2014-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease(COPD)

Brief summary

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Detailed description

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 90 Years

Healthy volunteers

Inclusion criteria

Mechanically Ventilated Patients Inclusion Criteria: Any Subject Mechanically Ventilated and producing sputum. Exclusion * None COPD Group Inclusion Criteria: * 40 to 90 years of age suffering from COPD * History of mucus production

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Sputum Collection	10 minutes	Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.

Countries

United States

Outcome results