Catheter-related Infection
Conditions
Keywords
vancomycin, levels, central venous port device, peripherally obtained levels, dose adjustments, TDM
Brief summary
Recently, it was reported that when vancomycin levels are determined after port sampling, levels can be falsely increased potentially leading to wrong dose adjustments. The investigators conducted an in vitro experiment using several central venous port devices, in which different flushing techniques were evaluated yielding residual vancomycin levels of less than 0.5 mg/L. In this study, the investigators want to evaluate this flushing technique in vivo in 15 patients admitted with catheter-related infection and treated with systemic vancomycin and vancomycin antibiotic lock. The purpose is to assess if correct flushing can avoid spurious vancomycin levels obtained via port sampling.
Interventions
PROCEDUREblood levels
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients, * having central venous port device, * treated with systemic vancomycin in combination with vancomycin antibiotic lock
Exclusion criteria
* pregnant women, * children, * patients with 'do not resuscitate' (DNR) code
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| comparison of central (via port device) and peripherally obtained vancomycin levels: the difference, when using the new flushing technique, is allowed to be maximally 0.5 mg/L | central and peripheral vancomycin levels will be obtained during steady state: this means starting from the 4th dose (= day 2) of vancomycin treatment. Vancomycin is usually given during 14 days after the last positive blood culture. |
Contacts
Primary ContactIsabel Spriet, PharmD PhD
Backup ContactJan Verhaegen, MD PhD
Outcome results
None listed