Exercise Test and Cardiac Injury

The Effect of Remote Ischemic Preconditioning on Plasma Troponin I Appearance After a Standardized Cycling Test in Healthy Volunteers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01660828

Enrollment

Registered

2012-08-09

Start date

2011-09-30

Completion date

2012-01-31

Last updated

2012-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease

Keywords

Exercise induced (high sensitive) troponin release, Ischemia reperfusion injury, Remote ischemic preconditioning

Brief summary

Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply that mimic those of ischemia and reperfusion injury. If the mechanism underlying the troponin release during exercise is similar to that of ischemia reperfusion injury (IRI), than it should be susceptible to remote ischemic preconditioning (RIPC) as RIPC is a well validated technique to reduce IRI. To test this hypothesis healthy volunteers underwent a strenuous exercise test with or without preceding RIPC.

Interventions

OTHERremote ischemic preconditioning (RIPC)

RIPC protocol which consist of three 5-min cycles of bilateral forearm ischemia

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* age: 18-45 year * willing to sign informed consent * healthy

Exclusion criteria

* hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \> 90 mmHg) * any cardiovascular abnormality in past medical history, physical examination or ECG, including QTc interval * drug abuse * alcohol abuse (\> 3 units/day) * smoking during the last 2 years * BMI \>30 kg/m2 * inability to perform bicycle test * the presence of an absolute or relative contra-indication for exercise (table 2 in protocol) * the presence of diabetes (fasting glucose \> 6.9 mmol/L, non-fasting glucose \>11.0 mmol/L; if non-fasting glucose is \> 6.9 mmol/L, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/L) * total cholesterol in blood 6.6 mmol/L or higher

Design outcomes

Primary

Measure	Time frame	Description
serum level of high sensitive troponin at several timepoints	timepoints t= baseline, 0, 1, 2, 3,4 and 8 hours after finishing exercise	serum level of high sensitive troponin in response to intensive exercise test with or without RIPC at several timepoints

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026