Community-acquired Pneumonia
Conditions
Keywords
pneumonia, anti-bacterial agents, (cost)efficacy
Brief summary
The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.
Interventions
OTHERPreferred empirical treatment
The investigators are using a cluster-randomized cross-over design for preferred empirical treatment. One of the 3 treatment arms is used as preferred empirical therapy during a period of 4 consecutive months, after which preferred treatment will rotate to 1 of the other 2 regimens. The order of change is randomised per hospital, thereby controlling for inter-hospital variables and minimizing seasonal influences.
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
UMC Utrecht
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients admitted to one of the participating hospitals needing treatment for CAP, not being admitted to the ICU are eligible for study inclusion. * Admission is defined as hospital stay for more than 24 hours.
Exclusion criteria
* Patients who are readmitted with CAP within 2 weeks after a previous episode are not eligible. * Patients with cystic fibrosis are not eligible.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Day 90 Mortality | 90 days from admission | We will assess all-cause mortality on day 90 from admission from the municipal personal records database |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of intravenous antibiotic treatment | Participants will be followed for the duration of hospital stay, an expected average of 1 week | — |
| Length of hospital stay | Participants will be followed for the duration of hospital stay, an expected average of 1 week | — |
| Tolerability | Participants will be followed for the duration of hospital stay, an expected average of 1 week | Side-effects and complications from antibiotic therapy are registered from clinical record |
| Complications | Participants will be followed for the duration of hospital stay, an expected average of 1 week | Complications of pneumonia during admission are registered from clinical record. |
| Health care costs and non-health care costs | 28 days from admission | Health care costs and non-health care costs are assessed using a short questionnaire 28 days from admission |
Countries
Netherlands
Outcome results
None listed