Stomach Cancer, Subtotal Gastrectomy
Conditions
Brief summary
Erythromycin has a prokinetic effect through Motilin receptor. It evokes migrating motor complex with longer and stronger contraction. In patients with upper gastrointestinal bleeding, It has been shown that erythromycin could clear the stomach of blood, so visual examination could be improved. Frequent food stasis is encounted when we examine patients with subtotal gastrectomy. It is postulated that erythromycin reduce food stasis and help to improve endoscopy in these cases.
Interventions
DRUGErythromycin
125mg in normal saline single use infusion for 5 min.
Sponsors
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who undergone STG (billroth I, billroth II, R-Y STG) within 5 years to treat gastric cancer * Stage of T1-2N0M0
Exclusion criteria
* concomitant therapy with astemizole, cisapride, dihydroergotamine, ergotamine, pimozide, or terfenadine, narcotics, alpha-2-adrenergic agonist, TCA, CCB, dopamine agonist, muscarinic cholinergic antagonists, octreotide, exenatide and GLP-1 agonist, phenothiazines * chemotherapy Hx. * hypersensitivity to erythromycin or any component of the product * pregnancy or lactation * comobidity : DM, AIDS, neurologic disease(parkinsonism, multiple sclerosis, brainstem stroke or tumor, diabetic or amyloid neuropathy, or primary dysautonomias) scleroderma and other connective tissue disease, recent viral enteritis history * recurrence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| degree of food stasis | when endoscopy is performed. | ref\> Gastric Cancer (2002) 5: 83-89 |
Countries
South Korea
Outcome results
None listed