Periodontitis
Conditions
Keywords
IgG titer, periodontopathic bacteria
Brief summary
This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Detailed description
Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.
Interventions
None listed
Sponsors
Okayama University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* periodontal patients * adults
Exclusion criteria
* difficulty of communication * received periodontal therapy within 3 months * with other diseases, i.e., hypertension, diabetes (self reported)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of IgG antibodies in serum/plasma against periodontal pathogens | 1 to 3 months after basic periodontal treatment (Scaling and root planing) | Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the ELISA method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal pocket depth | 1 to 3 months after basic periodontal treatment | Clinical observation on periodontal pocket depth before and after basic periodontal treatment, in order to confirm appropriate effects of the treatment. |
| Bleeding on probing | 1 to 3 monthsafter basic periodontal treatment | Judging from bleeding from gingiva after periodontal pocket probing, degree of inflammation will be understood. |
| Tooth mobility | 1 to 3 months after basic periodontal treatment | Clinical observation to understand decrease of inflammation |
Countries
Japan
Outcome results
None listed