The Effect of Calorie Deprivation on Adipose Tissue Distribution

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01658397

Enrollment

Registered

2012-08-07

Start date

2012-09-30

Completion date

2014-07-21

Last updated

2017-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy subjects, Fasting, Weight loss

Brief summary

In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters. We will be measuring changes in bone marrow fat using magnetic resonance spectroscopy and will use MRI to measure subcutaneous and visceral fat depots. Our hypothesis is that levels of bone marrow fat will increase after an acute fast.

Interventions

BEHAVIORALFasting

Ten day fast

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Men and women, ages 21-45 years * 101-130% of ideal body weight as defined by the 1983 Metropolitan Life Insurance Height and Weight Tables * Normal thyroid function * Regular menses (women) * Normal liver transaminases

Exclusion criteria

* Any disease known to affect bone metabolism, including untreated thyroid dysfunction, Cushing's syndrome, or renal failure * Any medication known to affect bone metabolism -- including systemic steroids or immunosuppressants -- within three months of the study, excluding estrogen and progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be excluded from participating for six months after their last injections. Bisphosphonates must have been discontinued for at least one year before participation * Serum potassium \<3.0 meq/L * Pregnant and/or breastfeeding (women) * Diabetes mellitus * Active substance abuse, including alcohol * Contraindications to MRI: cardiac pacemaker, metal implants, claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
Change in Bone Marrow Adiposity over 10 day fasting period	Baseline, After 10 day fasting period	Bone marrow adiposity will be measured before and after the 10 day fast using magnetic resonance spectroscopy.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026