Schizophrenia Imaging

Prospective Ultrasonographic and Magnetic Resonance Imaging (MRI) Assessment of General and Brain Fetal Development in Offspring of Schizophrenic Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01655472

Enrollment

Registered

2012-08-01

Start date

2012-07-31

Completion date

2015-07-31

Last updated

2012-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Foetal Differences Between Healthy and Schizophernic Parents

Keywords

schizophrenia, imaging

Brief summary

Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia. Structural neuroimaging studies have provided consistent evidence for brain abnormalities in schizophrenia. The timing of brain abnormalities in schizophrenia has not been determined yet. The investigators hypothesize that brain structural changes can be detected in neonatal life. The investigators hypothesize that offspring of schizophrenic patients will have higher rates of brain structural changes in the neonatal period. The investigators propose to study early development of fetuses in offspring of patients with schizophrenia. The study is a multi-center prospective trial.

Interventions

DEVICEimaging follow up: MRI scan

.1 Psychiatric interview. 2. Questionnaires 3. Blood samples for triple test: alfa feto protein, HCG, E3 4. A thorough fetal ultrasound examination including anatomic screening on 23-24 weeks of pregnancy. 5. A detailed trans-vaginal neurosonographic multi-planer examination, on 32-34 weeks of pregnancy 6. Fetal MRI scan on 32-34 weeks of pregnancy, 7. Newborn brain transfontanelar ultrasonography ,within 2 months postpartum 8. Newborn medical examination within 2 months postpartum.

DEVICEimaging follow up: Ultrasonographic examination

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Pregnant women who carry an offspring of a schizophrenia patient: whether the mother, the father or both suffer from schizophrenia.

Exclusion criteria

* Alcohol or drug abuse of pregnant woman * Past history or present occurrence of major neurologic or somatic illness * Genetic disease * Other psychiatric disorders other than schizophrenia such as Mental retardation * Bipolar Disorder and Delusional Disorder

Design outcomes

Primary

Measure	Time frame	Description
Brain morphological changes between groups	2 years	Both MRI scans and US scans will be compared between the groups, assessing brain morphological and volumetric differences .

Countries

Israel

Contacts

Primary ContactNivi Rotenberg, M.D

nivirot@gmail.com972-50-7744593

Backup ContactMiki Bloch, M.D.

mikib@tlvmc.gov.il

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026