Rapid Ventricular Response Atrial Fibrillation
Conditions
Brief summary
Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments. This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.
Interventions
DRUGPropranolol
DRUGMetoprolol
DRUGVerapamil
DRUGDiltiazem
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age more than 18 years old * Stability in hemodynamic
Exclusion criteria
* Systolic blood pressure less than 90 mm Hg * Altered mental status attributable to rapid ventricular response atrial fibrillation * Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation * Chest pain attributable to rapid ventricular response atrial fibrillation * Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem * History of asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate less than 100 per minute | In 1 hour | Ventricular rate less than 100 per minute after 1 hour of per oral medication administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Drugs adverse effects | 2 hours | Drugs adverse effects seen in patients in 2 hours after per oral medication administration |
| Unstability in hemodynamic | 2 hours | Hemodynamic instability (systolic blood pressure less than 90 mmHg, loss of consciousness, pulmonary edema, chest pain) |
Countries
Iran
Outcome results
None listed