Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01653002

Enrollment

200

Registered

2012-07-30

Start date

2012-02-29

Completion date

2014-06-30

Last updated

2016-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer With Mediastinal Lymph Node Involvement

Keywords

Lung cancer, EBUS-TBNA, Epigenetics, shox2 protein, human

Brief summary

A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.

Interventions

OTHERNo intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* clinical diagnosis of lung cancer * enlarged mediastinal or hilar lymph nodes (\>10 mm)

Exclusion criteria

* clinical condition which excludes general anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic Performance of SHOX2	one Year	Diagnostic performance of SHOX2 methylation Level as biomarker for lung cancer compared to histologic evaluation of EBUS-TBNA specimen alone.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026