One Lung Ventilation
Conditions
Keywords
positive end expiratory pressure
Brief summary
Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .
Detailed description
outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)
Interventions
OTHERPEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II * age: 20-75 years
Exclusion criteria
* moderate to severe impaired respiratory function, * heart failure, * patients' refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PaO2, number of patients with hypoxia (PaO2< 90mmHg) | participants will be followed for the duration of anesthesia, an expected average of 3 hours | blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| intrapulmonary shunt | participants will be followed for the duration of anesthesia, an expected average of 3 hours | blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV |
Countries
South Korea
Outcome results
None listed