Hypoxia
Conditions
Keywords
high flow nasal oxygen therapy, diagnostic bronchoscopy
Brief summary
The purpose of this study is to determine the efficacy and safety of nasal high flow oxygen therapy during diagnostic bronchoscopy.
Detailed description
Hypoxemia is frequently seen during diagnostic bronchoscopy. Nasal prong or other existing oxygen supply methods are often difficult to maintain adequate oxygenation during bronchoscopy. In particular, bronchoscopy to patients already showing hypoxemia can be dangerous even though applying conventional oxygen therapy. Thus, we want to elucidate the usefulness of nasal high flow oxygen therapy to hypoxemic patients undergoing diagnostic bronchoscopy.
Interventions
DEVICEHFNOT
high flow nasal oxygen therapy
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1 or 2 1. PaO2 \< 60 mmHg on ABGA or SpO2 \< 90 % in room air AND SpO2 ≥ 95% or PaO2 ≥ 75mmHg in low flow oxygen therapy 2. Planning to diagnostic bronchoscopic procedure (e.g. bronchial washing, BAL, bronchoscopic biopsy, EBUS-TBNA etc.)
Exclusion criteria
1. patients who did not agree to provide information 2. patients requiring for emergent intubation 3. patients can not wear or be already applied high flow nasal oxygen therapy 4. patients with unstable vital sign(e.g. severe hypotension, uncontrolled arrhythmia, etc.) 5. patients with multiple organ failures 6. patients with plan to therapeutic bronchoscopic procedure(e.g. intervention)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success rate of bronchoscopy | 1 day | Success is defined as completion of planned diagnostic procedure with the oxygen saturation or partial pressure of oxygen in arterial blood was similar to the level of before the procedure. Failure is defined as incompletion of planned diagnostic procedure due to sustained hypoxemia or else. Furthermore failure is defined as hypoxemia(SaO2 \<88%) was developed more than 2 times even though planned procedure was completed. |
| Total duration of hypoxia | 1 day | total duration of hypoxia(oxygen saturation ≤88%) during procedure or after procedure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| frequency of hypoxia | 1 day | frequency of hypoxia(oxygen saturation ≤88%) during procedure or after procedure. |
| switch to oxygen therapy method | 1 day | Increase oxygen apply or change of oxygen therapy method to high flow system. |
| change of respiratory symptoms | 1 day | scoring of dyspnea symptoms, patients comfort. |
Countries
South Korea
Outcome results
None listed