Evaluation of Hemodynamics and Amount of Blood Flowing Through the Kidneys During Liver Transplant by Measuring Some Physiological Substances in Blood and Urines

Evaluation of Sodium Urinary Excretion, Chlorine Urinary Excretion, Urinary Partial CO2 Pressure as Renal Perfusion Indicators During Liver Transplant. Comparison With Other Polemic State Indicators (Such as PiCCO, ScvO2, O2 Delivery).

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01650116

Enrollment

Registered

2012-07-26

Start date

2012-07-31

Completion date

2015-12-31

Last updated

2014-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovolemia During Liver Transplantation, Renal Hypoperfusion During Liver Transplantation

Keywords

hypovolemia, renal hypoperfusion, liver transplantation, sodium, chloride, PuCO2, ScvO2, PiCCO, O2-delivery, hemodynamic indexes

Brief summary

The purpose of this study is to verify any existing relationship between urinary parameters (such as excretion of sodium, chlorine, urinary partial CO2 pressure \[PuCO2\]) and general volemic indicators (such as PiCCO, ScvO2, O2 delivery) during liver transplant.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* surgery for liver transplantation * age 18-75 * ASA class I-III

Exclusion criteria

* age above 75 or under 18 * ASA class IV * pre-existing renal failure * pregnant patients * patients unable to give written consent

Design outcomes

Primary

Measure	Time frame
Determination of hemodynamic indicators (PiCCO, ScvO2, O2-delivery) and three urinary analytes (sodium, chloride, CO2 partial pressure)	During the stay of the patient in the operating room (in average 8 hours) and the subsequent stay in the post-surgery intensive care unit (in average 5 days)

Countries

Italy

Contacts

Primary ContactPaolo Feltracco, M.D.

paolofeltracco@inwind.it+393493410225

Backup ContactAndrea Bortolato, M.D.

freeandrea.b@libero.it+393316169933

Outcome results