- Study Focus: Renal Retention of Lipid Microbubbles
Conditions
Brief summary
Flank pain has been reported with ultrasound (US) contrast agents. The purpose of this study is to determine whether there is retention of ultrasound contrast agents in the renal microcirculation, which has been described in mice.
Detailed description
In this study patients undergoing clinically indicated contrast echocardiography will have renal ultrasound performed 10 minutes after completion of contrast infusion to determine the presence and location of renal retention of lipid microbubbles.
Interventions
None listed
Sponsors
Oregon Health and Science University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Undergoing clinically indicated contrast echo * adequate renal ultrasound images
Exclusion criteria
* chronic inflammatory disease * known kidney disease * immunomodulatory therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal Video Intensity Units | 10 min | Video intensity units in the kidney 10 min after completion of a clinically indicated contrast echocardiography study. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Contrast Administration Patients undergoing contrast-enhanced echo. | 10 |
| Total | 10 |
Baseline characteristics
| Characteristic | Contrast Administration |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 2 Participants |
| Age, Categorical Between 18 and 65 years | 8 Participants |
| Region of Enrollment United States | 10 participants |
| Sex: Female, Male Female | 4 Participants |
| Sex: Female, Male Male | 6 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 10 |
| serious Total, serious adverse events | 0 / 10 |
Outcome results
Primary
Renal Video Intensity Units
Video intensity units in the kidney 10 min after completion of a clinically indicated contrast echocardiography study.
Time frame: 10 min
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Contrast Administration | Renal Video Intensity Units | 19 units on a scale | Standard Deviation 9 |