Osteoarthritis, Knee
Conditions
Keywords
Knee osteoarthritis, Total knee arthroplasty, Preoperative training, Strength training
Brief summary
The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).
Detailed description
Reduced strength of the quadriceps muscle is a common clinical finding in patients with Knee Osteoarthritis and this seems to play a central role in the development of the disease. The strength of the quadriceps muscle have been shown to be reduced by 20-40% as compared to age-matched healthy controls and this decrease in muscle strength have been closely associated with a reduced level of function and increase of pain. Furthermore, it has been demonstrated that the preoperative strength of the quadriceps muscle in patients undergoing TKA, is associated with the level of function one year after surgery. Compared to the level before the operation, an additional operation-induced reduction of the strength of the quadriceps muscle up to 60% as has been demonstrated. Presumably, an optimizing of the strength of the quadriceps muscle could counteract the impact of the expected postoperative loss of muscle strength to such an extent that the loss will be of less clinical significance. It is hypothesized that an optimizing of the strength of the quadriceps muscle may have a favorable effect on the postoperative rehabilitation program and shorten the period of convalescence.
Interventions
OTHERPreoperative strength training
Progressive strength training on group basis (not more than 3 subjects) 3 sessions weekly starting 4 weeks before the operation, in total 12 sessions Strength training 3 sessions weekly 4 weeks postsurgery
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Planned TKA at the Aarhus University Hospital or Region Hospital Silkeborg, * Living in Aarhus Municipality, * Primary knee osteoarthritis or secondary osteoarthritis after meniscectomy or ligament injury
Exclusion criteria
* Unstable blood pressure, * Neuromuscular or neurodegenerative disease, * Comprehension or dementia problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Primary outcome: Sit-to-stand test | Change from Baseline 6 weeks preoperative in Sit-to-Stand at 6 weeks postoperative | Ability of function test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Isokinetic: Hamstrings 60 gr./sek | 6 weeks and 1 week before the operation, 1 week, 6 weeks 12 weeks and 1 year after the operation | Muscle strength test in dynamometer |
| Isometric: Quadriceps (70 gr. flexion) | 6 weeks and 1 week before the operation and 11 week, 6 weeks, 12 weeks and 1 year after the operation | Muscle strength test in dynamometer |
| Isometric: Hamstrings (20 gr. flexion) | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Muscle strength test in dynamometer |
| Rate of force development (flexion and extension) | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Muscle test in dynamometer |
| Timed Up and Go | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Ability of function test |
| 10 meter walk test | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Ability of function test |
| 6 minute walk test | 6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Ability of function test |
| Isokinetic: Quadriceps 60 gr./sek | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Muscle strength test in dynamometer |
| Oxford Knee Score (OKS) | 6 weeks before the operation and 6 weeks after | Disease-specific questionnaire |
| EuroQol-5 dimensions (EQ-5D) | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Generic questionnaire for self-rated health |
| Short-Form Health Survey (SF 12) | 6 weeks before the operation and 1 year after | Generic questionnaire for self-rated health |
| Background data questionnaire | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Questionnaire about pain, medicine use, alcohol intake, smoking, education, job |
| Range of motion of the knee | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Extension of the knee Flexion of the knee |
| Body mass index | 6 weeks and 1 week before the operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Weight/height2 |
| Knee injury and Osteoarthritis Outcome Score (KOOS) | 6 weeks and 1 week before operation, 1 week, 6 weeks, 12 weeks and 1 year after the operation | Disease-specific questionnaire |
Countries
Denmark
Contacts
Primary ContactBirgit Sørensen Skoffer, MPH
Outcome results
None listed