Gastric Intestinal Metaplasia
Conditions
Keywords
Gastric Intestinal Metaplasia, Confocal Laser Endomicroscopy
Brief summary
The study aims to: 1. Explore the properties of mesenchymal black spots, and to determine the value of mesenchymal black spots in diagnosing gastric intestinal metaplasia by confocal laser endomicroscopy (CLE). 2. Evaluate the incidences of gastric intraepithelial neoplasia and gastric cancer in patients with gastric mesenchymal black spot during CLE imaging.
Detailed description
Gastric intestinal metaplasia (GIM) is confirmed to be a risk factor that may lead to the development of intestinal type gastric cancer. Previous study has shown that confocal laser endomicroscopy promising in the diagnosis of GIM. The investigators have found an elevated incidence of mesenchymal black spots in patients with GIM during previous CLE imaging. This study aims to explore the properties of mesenchymal black spots, and to determine the value of mesenchymal black spots in diagnosing gastric intestinal metaplasia by confocal laser endomicroscopy.
Interventions
PROCEDURECLE examination for upper gastrointestinal tract
Routine upper GI endoscopy plus targeted CLE examination
Sponsors
Shandong University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients will include male or female aged between 18 and 80 years with indications for upper-endoscopy , but without any disease of heart, liver or kidney.
Exclusion criteria
* Patients who are allergic to fluorescein sodium * Patients who are unwilling to sign or give the informed consent form * Patients with impaired cardiac, liver or renal function * Patients with coagulopathy * Patients with pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of black spots in diagnosis of gastric intestinal metaplasia | up to six months |
Countries
China
Contacts
Primary ContactYanqing Li, MD, PhD
Outcome results
None listed