Hyperlipidemia, Insulin Resistance, Obesity
Conditions
Keywords
Obese, insulin sensitive, insulin resistant, myotubes, lipid accumulation
Brief summary
The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.
Detailed description
Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.
Interventions
OTHERLipid accumulation analysis
The lipid accumulation will be assessed with muscular biopsies.
Sponsors
University Hospital, Montpellier
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2 * Patients who do not practice physical exercise (Voorips index \< 9) * Age between 40 and 70 years- Male gender * Fast blood glucose \<1,10 g/l and no hypoglycemic treatment * Signed informed consent * Social security affiliation * Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen * Normal biological tests * Non smoking persons
Exclusion criteria
* Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests * Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory. * Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy * Allergy to local anaesthetic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lipid accumulation in skeletal muscle | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| lipid accumulation in myotubes from obese patients | 1 month |
Countries
France
Outcome results
None listed