Collapsibility of the Inferior Vena Cava
Conditions
Keywords
Diaphragmatic excursion, normality
Brief summary
The main objective of this study is to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 50% collapsibility of the inferior vena cava.
Detailed description
Secondary objectives of this study are: * to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 40% collapsibility of the inferior vena cava (IVC). * to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 100% collapsibility of the IVC. * to determine the location of the cutting plane for the TM analysis of collapsibility of the IVC. * to evaluate the hemodynamic conditions of normal healthy volunteers. * to detect any abnormality of cardiac function.
Interventions
PROCEDUREUltrasounds with controlled breathing
The patient will have cardiac, abdominal and thoracic ultrasounds with controlled and monitored inspiratory effort. This gesture takes about 40 minutes.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* The volunteer must have given his/her informed and signed consent * The volunteer must be insured or beneficiary of a health insurance plan
Exclusion criteria
* The volunteer is participating in another study * The volunteer is in an exclusion period determined by a previous study * The volunteer is under judicial protection, under tutorship or curatorship * The volunteer refuses to sign the consent * It is impossible to correctly inform the volunteer * The patient is pregnant, parturient, or breastfeeding * The volunteer has known heart disease like heart failure, cardiac arrhythmia * The volunteer takes cardiotropics * The volunteer has known lung disease: obstructive or restrictive respiratory failure * The volunteer has clinical signs of COPD (coughing with morning sputum in a smoking subject) * Any emergency situation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Collapsibility score for the IVC diameter | Baseline (Day 0; cross-sectional study) | percentage = ((max-min)/average)\*100% Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is \>= 50%; and (3) a measure of the diaphragmatic excursion. |
| Collapsibility score for the IVC diameter >= 50% (presence/absence) | Baseline (Day 0; cross-sectional study) | percentage = ((max-min)/average)\*100% Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is \>= 50%; and (3) a measure of the diaphragmatic excursion. |
| Diaphragmatic excursion | Baseline (Day 0; cross-sectional study) | Maximum distance between the position of the diaphragmatic dome during inspiration versus expiration (cm) Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is \>= 50%; and (3) a measure of the diaphragmatic excursion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mitral Doppler Wave A speed | Baseline (Day 0; cross sectional study) | cm/s |
| Collapsibility score for the IVC diameter >= 40% (presence/absence) | Baseline (Day 0; cross sectional study) | percentage = ((max-min)/average)\*100% |
| Simpson: FEVG | Baseline (Day 0; cross sectional study) | % |
| Tissue Doppler Wave E' speed | Baseline (Day 0; cross sectional study) | cm/s |
| Collapsibility score for the IVC diameter >= 60% (presence/absence) | Baseline (Day 0; cross sectional study) | percentage = ((max-min)/average)\*100% |
| Mitral Doppler Wave E speed | Baseline (Day 0; cross sectional study) | cm/s |
Countries
France
Outcome results
None listed