Cytokine Profiling Post-Heart Transplant

Cytokine Profiling of Cardiac Transplant Recipients

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01643564

Enrollment

Registered

2012-07-18

Start date

2011-11-30

Completion date

2012-06-30

Last updated

2023-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Transplant

Keywords

Transplant, Cytokines, Graft Dysfunction

Brief summary

Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Group 1 * 18 years and older * Cardiac Transplant recipient with graft dysfunction of unknown etiology Group 2 * 18 years or older * No history of heart failure or cardiac transplantation Group 3 * 18 years or older * Class II-IV heart failure Group 4 * 18 years or older * Heart Transplant 6 months or greater prior to blood draw * No graft dysfunction

Exclusion criteria

Group 1 Heart Transplant with Unexplained Graft Dysfunction * Cellular or antibody-mediated cardiac allograft dysfunction Group 2 Normal Control group * Active infection within 1 month of blood draw * Known Inflammatory Disease Group 3 Heart Failure Group * Active infection within 1 month of blood draw * Known Inflammatory Disease Group 4 Heart Transplant with Normal Graft Function Group * Active infection within 1 month of blood draw * Known graft dysfunction * Known Inflammatory Disease

Design outcomes

Primary

Measure	Time frame	Description
Differences in cytokine profiles between stable heart transplant recipients and those with acute rejection	12 months	Differences in cytokine profiles between stable heart transplant recipients and those with acute rejection

Outcome results