Advanced Heart Failure, Left Ventrucular Assist Device
Conditions
Keywords
Heart Failure, Left Ventricular Assist Device, Reperfusion Injury, Neuron Specific Enolase
Brief summary
An observational study of neuron specific enolase, as a marker of reperfusion injury, in LVAD recipients before and following VAD implantation.
Detailed description
Patients eligible for left ventricular assist device (LVAD) typically have severe heart failure, which is characterized by poor cardiac output. The relatively abrupt increase in cardiac output that follows implant of a LVAD may cause reperfusion injury. Furthermore, selected patients may have particularly severe consequences of such injury, including refractory acidosis and vasoplegia. Neuron specific enolase (NSE) has been established as a biomarker of reperfusion injury. We hypothesize that changes in NSE following LVAD will be greater than the changes in NSE noted in a control population of patients undergoing non-VAD cardiac surgery.
Interventions
None listed
Sponsors
University of Minnesota
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Group 1 - Pre-VAD implantation patients * 18 years and older * lanning to undergo VAD implantation Group 2 Cardiac Surgery Comparison Group * 18 years or older * Planning to undergo valve or coronary bypass surgery
Exclusion criteria
* Acute cerebrovascular infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuron-Specific Enolase | Pre and post-surgery |
Countries
United States
Outcome results
None listed