Improvement of Cardiovascular Autonomic Control., Improvement of Functional Capacity., Improvement of Quality of Life.
Conditions
Brief summary
The purpose of this study is to determine the effects of a deep inspiration combined to expiratory positive airway pressure protocol on respiratory function, quality of life, exercise tolerance and heart rate variability in adults with severe asthma.
Detailed description
Asthma is associated with high morbidity and significant mortality. This disease has functional impact on activities of daily living (ADLs) and according to some studies in the United States and Europe, the percentage of asthmatics who have significant restrictions in their ADLs is quite significant. Asthma is characterized as a major public health problem, not only in Brazil but worldwide. Currently there are few studies reporting the effects of a domiciliary program of deep inspiration associated with positive expiratory pressure in the airways of asthmatics. This study aims to analyze the benefits of this program on lung function, quality of life and response to exercise.
Interventions
OTHERDeep inspiration and positive expiratory airway pressure
It was used a device the combines deep inspiration and positive expiratory airway pressure in asthmatic subjects, for 5 weeks, twice a day.
Sponsors
Federal University of Health Science of Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age between 20 and 80 * Severe asthma
Exclusion criteria
* Disagreement with consent form * Other respiratory disease * Acute severe asthma * Pregnancy or breastfeeding * Current smoking * Lack of capable of conducting the study visits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The effect of deep inspiration and positive expiratory airway pressure in quality of life in adults with severe asthma | Change in quality of life at 5 week | The quality of life will be measure by a specific questionnaire for this population 5 weeks apart. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The effect of deep inspiration and positive expiratory airway pressure in respiratory function in adults with severe asthma. | Change in respiratory function at 5 week | The respiratory function will be measure by spirometry 5 weeks apart. |
| The effect of deep inspiration and positive expiratory airway pressure in heart rate variability in adults with severe asthma. | Change in heart rate variability at 5 week | The heart rate variability will be measure by the acquisition of electrocardiogram signal 5 weeks apart. |
| The effect of deep inspiration and positive expiratory airway pressure in exercise tolerance in adults with severe asthma. | Change in exercise tolerance at 5 week | The exercise tolerance will be measure by 6 minute walk test 5 weeks apart. |
Countries
Brazil
Outcome results
None listed