Retinoblastoma
Conditions
Keywords
retinoblastoma
Brief summary
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells know to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
Interventions
None listed
Sponsors
Stanford University
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 5 Years
Healthy volunteers
No
Inclusion criteria
* Patient must have retinoblastoma * Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care. * Parental consent
Exclusion criteria
* Diagnosis other than Retinoblastoma * No surgical sampling of tumor is planned as part of standard care * Parental preference to not participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in efficiency of reprogramming in cells with naturally occurring retinoblastoma mutations | After appropriate time, e.g., 7, 10, 14 days after reprogramming | Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming. |
Countries
Guatemala, United States
Outcome results
None listed