Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01642576

Enrollment

Registered

2012-07-17

Start date

2010-07-31

Completion date

2014-04-30

Last updated

2015-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Dysfunction, Inflammation, Quality of Life, Sexual Dysfunction

Keywords

obesity, men, sexual function, urinary tract symptoms, endothelial function, inflammation, quality of life

Brief summary

This study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.

Interventions

BEHAVIORALweight loss counselling

Diet counselling with or without sports trainers, over 8 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Male, aged 30-65 years * Body Mass Index (BMI) \>/= 27.5 kg/m2 * Waist circumference (WC) \>/= 90 cm

Exclusion criteria

* pituitary disease or cranial radiotherapy * previous or current androgen replacement or deprivation therapy * current treatment for sexual problems or LUTS * glomerular filtration rate \< 60 ml/min * liver disease * alcohol intake exceeding 500 g/week in the previous 12 months * use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors

Design outcomes

Primary

Measure	Time frame	Description
erectile function	8 months	IIEF-5 score

Secondary

Measure	Time frame	Description
lower urinary tract symptoms	8 months	IPSS score

Countries

Singapore

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026