The Impact of Whole Body Irradiation on Ocular Flare
Conditions
Keywords
Ocular flare
Brief summary
This is a longitudinal Feasibility Study of a novel non-invasive device in assessing radiation dose exposure in humans. All patients receiving whole body irradiation therapy and meeting all other inclusion/exclusion criteria will receive ocular flare meter measurements and slit-lamp examinations on up to eleven occasions starting prior to the first fractional dose of irradiation.
Interventions
None listed
Sponsors
University of California, Los Angeles
ChromoLogic, LLC
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects must be scheduled to receive whole body irradiation in a dose range from 1.5 to 12Gy. * Subjects must not have received ocular surgery for at least three months prior to study enrolment. * Subjects must not have a history of uveitis. * Subjects must have at least one eye free of cataracts * Subject age must be greater than 18 years * Subjects must have the ability to understand and willingness to sign a written informed consent document.
Exclusion criteria
* Inability to give informed consent * Cataracts in both eyes * Subject has received ocular surgery within the prior three months * Subject has a history of uveitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ocular flare in radiotherapy patients | Daily measurements for the duration of radiotherapy treatment (expected up to four days from start of treatment) | Determine if ocular flare meter spectra and/or a slit-lamp eye exam can assess radiation dose exposure in individual human radiotherapy patients. |
Countries
United States
Outcome results
None listed