The Effect of Eating Frequency on Blood Pressure

The Effect of Number of Eating Episodes Per Day on Blood Pressure. A Randomised Controlled Trial

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01640015

Enrollment

Registered

2012-07-13

Start date

2012-01-31

Completion date

2012-03-31

Last updated

2019-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure

Keywords

Blood pressure, eating episode, eating frequency, insulin sensitivity

Brief summary

The primary purpose of this study is to identify the effect of meal frequency on blood pressure (BP) levels of individuals.

Detailed description

Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels. Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.

Interventions

OTHERdietary intervention

a low frequency diet (3 meals/day) a high frequency diet (9 meals/day)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

35 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers

Exclusion criteria

* Weight change of ≥ 3kg in the preceding 2 months * Current smokers * Substance abuse * Alcohol intake * Pregnancy * Diabetes * Cardiovascular disease * Cancer * Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome * Kidney disease * Liver disease * Pancreatitis * Use of medications including: anti inflammatory drugs or steroids, antihypertensive drugs, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.

Design outcomes

Primary

Measure	Time frame	Description
blood pressure	2 weeks for 24 hours through blood pressure monitor	Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center.

Secondary

Measure	Time frame	Description
Insulin	measured twice during each phase (2 phases)	biomarkers like: Insulin - Glucose- lipid profile- Free fatty acids- C peptides- HS CRP will be measured regularly during study

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026