Nonalcoholic Steatohepatitis (NASH)
Conditions
Keywords
NASH; coronary artery disease
Brief summary
This study will evaluate the association of non-alcoholic fatty liver disease and coronary artery disease. All patients presenting for coronary angiogram will receive the following examination: * Transient Elastography and Controlled Attenuation Parameter using the FibroScan * blood examination including biochemical markers The results of non-invasive liver steatosis and fibrosis measurement are compared with the results of coronary angiogram concerning the presence or absence of coronary artery disease.
Interventions
DEVICETransient Elastography (FibroScan), Echosens, Paris, France
Sponsors
Johann Wolfgang Goethe University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female, 18 years and older * Written consent * Coronary angiogram planned
Exclusion criteria
* Patients with mental diseases * Pregnancy or lactation * Ascites
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver fibrosis scores I-IV (METAVIR) | — | METAVIR fibrosis scores: I = mild fibrosis II = significant fibrosis III = advanced fibrosis IV = cirrhosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Steatosis fibrosis scores I-III | — | Steatosis scores: 0 = \<5% I = 5-33% II = 33-66% III = \>66% |
Countries
Germany
Contacts
Primary ContactMireen Friedrich-Rust, MD
Outcome results
None listed