Healthy
Conditions
Keywords
Mechanism of Action of escitalopram
Brief summary
Healthy males were examined with positron emission tomography (PET) and the radioligand 11C-AZ10419369, before and after administration of a single dose escitalopram. A change in the binding potential of 11C-AZ10419369 between the baseline and the post-dose condition was hypothesized to reflect a change in serotonin concentration.
Interventions
DRUGEscitalopram
20 mg p.o.
Sponsors
Karolinska Institutet
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
1. Signed informed consent 2. Male gender 3. Age 20 to 30 years 4. Healthy according to physical examination, ECG, MRI and blood chemistry
Exclusion criteria
1. Past or present psychiatric disease 2. Past or present brain disorder or injury, including loss of consciousness for more than five minutes 3. Past or present drug or alcohol abuse 4. Past or present use of antidepressant or antipsychotic medications 5. Regular use of medications (including herbals), that could interfere with the pharmacodynamics or pharmacokinetics of escitalopram 6. Significant abnormality on ECG 7. Structural abnormality in the brain confirmed by MR examination 8. Claustrophobia 9. Any metal devises or implants in the body 10. Intolerance to escitalopram or any of the components of the formula 11. Predisposition to motion sickness 12. Inability to understand and comply with the study requirements 13. Any medical condition that, in the opinion of the investigator, make the subject unsuitable for the study or put the subject at additional risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in binding potential of 11C-AZ10419369 between baseline and post-dose condition | One day (PET measurement before and after escitalopram administration on the same day) |
Countries
Sweden
Outcome results
None listed